Accolades/Funding:

Congratulations to Michelle Ozaki, graduate student in the Schedin lab, who has been invited to present at the NIH F99/K00 Awardees Annual Meeting on her abstract titled, "The liver, under reproductive control, generates a pro-metastatic niche post-wean".

Congratulations to Dr. Jonathan Brody who, in collaboration with Dr. Jordan Winter (Case Western), has been award an R01 for his project, "Optimizing anti-wild-type IDH1 therapy in pancreatic cancer".

Congratulations to Dr. Lisa Coussens who is one of six OHSU researchers that have been named among the world’s most highly cited in 2023. The list, compiled each year by the Institute for Scientific Information at data analysis firm Clarivate, identifies global scientists whose exceptional influence is reflected through their publication of multiple papers frequently cited by their peers. Read more on OHSU Now.

Professor Teresa Zimmers organized the 7^th Cancer Cachexia Conference of the Cancer Cachexia Society in September 2023 in Edinburgh, Scotland. The meeting featured 250 participants from 23 countries, 70 speakers, 100 posters, 16 competitive awards, and networking and social events. The event was partially supported by an NCI R13 Grant, “Enhancing Diversity and Addressing Disparities at the 7th Cancer Cachexia Conference.” Teresa completed her term as President of the Cancer Cachexia Society and continues as ex-officio Board Member and Co-Chair of the Diversity, Equity & Inclusion and Patient Advocacy Committees.

Congratulations to Tori Schuster, graduate student in the Ruhland lab, who placed third for her poster presentation, "Multi-antigen management by dendritic cells within the melanoma microenvironment" at the 2023 Montagna Sympsoium on the Biology of Skin.

Congratulations to Dr. Megan Burger who is the recipient of the Lung Cancer Discovery Award from the American Lung Association Research Institute. Read about it here.

Congratulations to Dr. Josh Moreau who has received a Collins Medical Trust grant for his project, "Decoding the Antigenic Experience of Tissue Resident B Cells in Cutaneous Squamous Cell Carcinoma”.

Congratulations to Matthew Stern, graduate student in the Shree lab, who has received a T32 training grant aware for his project, "Tracking subclonal evolution in lymphoma via paired single-cell BCR and cancer genome sequencing".

Congratulations to Dr. Sud Anand who has been appointed as the new director of the Ph.D. Program in Biomedical Sciences (PBMS), succeeding Dr. Georgiana Purdy. Read more here.

Congratulation to Michelle Ozaki, graduate student in the Schedin lab, who has been award a prestigious F99 award from the NIH that provides funding for 2 years of graduate work and 3 years of postdoc support. The title of her project is, "Fibroblasts in the establishment of the liver pre-metastatic niche."

Congratulations to Dr. Caroline Enns who has recently been received the Marcel Simon Award. The award is presented every two years at the Bioiron Society meeting and is awarded for excellence in the research of genetic hemochromatosis.

Congratulations to Dr. Megan Burger who recently received a V Scholar grant from the V Foundation for Cancer Research.

Congratulations to Tori Schuster, graduate student in the Ruhland lab, has received a T32 training grant award for Interdisciplinary Training in Microbial Pathogenesis and Immunology.

Congratulations to Dr. Ranish Patel, Wong lab surgical resident, who won first prize for his talk at the WA/OR American College of Surgeons 2023 Annual Meeting.

Congratulations to Dr. Ranish Patel, Wong lab surgical resident, who won first place for his poster at the Northwest Colorectal Surgeons Meeting in July.

Congratulations to Robert Eil, M.D., and Alex Bartlett, Ph.D., who were the recipients of the 2023 Biomedical Innovation Program Drug Discovery award. The team aims to modify a therapy that currently treats blood cancers so that it will effectively fight solid tumors in the liver. Read more about the project and the OCTRI BIP program.

Congratulations to Dr. Brittany Counts, a postdoctoral scholar in the Zimmers’ Lab, who received a Brenden-Colson Center travel award to present her work at the 7^th Cancer Cachexia Conference in Edinburgh, Scotland.  

Congratulations to Dr. Pepper Schedin, Professor of Cell, Developmental & Cancer Biology, who has been appointed the inaugural recipient of the Leonard Schnitzer Chair in Breast Oncology. The Leonard Schnitzer Family established this endowed chair in Leonard’s memory to help advance clinically relevant cancer research and the work of the OHSU Knight Cancer Institute to end cancer as we know it. An investiture ceremony will be held later this summer to honor the family and Schedin. Read more here.

Congratulations to Brittany Counts, Ph.D., a postdoctoral scholar in the Zimmers’ Lab, who was selected to present at the 2023 Next Generation Researchers in Cancer Cachexia.

Congratulations to the below Wong lab members for the following accolades:

• Ranish Patel (surgical resident) is the recipient of the Inaugural Jonathan Brody Research Resident Award for excellence in academic Research
• Ashley Anderson, graduate student, is the recipient of a Knight SciOps grant.
• Ashley Anderson, graduate student, was selected for a short talk titled, "Multi-omic and imaging single cell analyses identify neoplastic-immune hybrid cell properties for metastatic progression in colorectal cancer" at Keystone Symposia's Single Cell Biology: From Development to Cancer in June 2023.

Congratulations to Dr. Jonathan Brody who was elected to the Scientific and Medical Advisory Board for the National Pancreatic Cancer Action Network organization.

Congratulations to Dr. Jonathan Brody and the Brody lab who, in collaboration with Dr. Michael Pishvaian at Johns Hopkins, received a Lustgarten Accelerator Award.

Congratulations to Zihan Guo, graduate student in the Pucci lab, who received a Travel for Techniques (TfT) award from AAI.

Congratulations to Dr. Joshua Moreau who received a grant from the Leo Foundation for his project, "Unravelling B cell dynamics in hidradenitis suppurativa pathogenesis." Read about it here.

Congratulations to Dr. Julia Maxson who received the OHSU Richard T. Jones Distinguished Alumni Scientist Award. Read more about it here.

Congratulations to Kaelan Byrd, a 2nd year MD student at OHSU who is completing his Masters in Clinical Research in the Moran lab, has been award an inaugural fellowship from the Physician-Scientist Support Foundation.

Congratulations to Dr. Megan Burger who received the Lung Cancer Discovery Award from the American Lung Association for her project, "Promoting cooperative T cell responses against lung cancer."

Congratulations to Dr. Jonathan Brody who received a Distinguished Service Award from the Department of Surgery for his work on research, mentoring, and DEI mission in the department.

In recognition of her scientific work and contributions to the field of cancer research, Lisa Coussens, Ph.D. was elected to the National Academy of Sciences, among 143 other newly elected members. Membership is a widely recognized mark of excellence in science, and one of the highest honors that a scientist in the United States can receive. Congratulations, Dr. Coussens! Read more on OHSU Now.

Congratulations to Hatun Duran Cete, MD, a postdoc in the Schedin lab, who is studying ways to target postpartum breast cancer and will be supported by an OHSU Fellowship for Diversity in Research. Breast cancers diagnosed within 5 years of childbirth have a 2-3-fold increased risk of liver metastasis. She will investigate the metastatic environment within the liver that facilitates breast cancer establishment in postpartum women, and will use mouse models of PPBC to investigate mechanisms. Featured on OHSU Now.

Publications:

Dr. Anupriya Agarwal and the Agarwal lab recently published, "Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells" in Nature Communications.

Dr. Joshua Moreau and the Moreau lab recently published, "Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa" in JCI Insight.

The Eil lab has recently published their first last author paper, "Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function" in Cancer Immunology Research. CIR has selected the paper for a spot-light commentary as well.

Dr. Ranish Patel, surgery resident in the Wong lab, has published a collaborative review titled "Updated Management of Colorectal Cancer Liver Metastases: Scientific Advances Driving Modern Therapeutic Innovations" in Cellular and Molecular Gastroenterology and Hepatology.

The Coussens lab has 7 publications to announce from 2023:

• "Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in metastatic pancreatic ductal carcinoma patients" in the Journal of ImmunoTherapy for Cancer.
• "Alignment, segmentation, and neighborhood analysis of cyclic immunohistochemistry data using CASSATT" in Cytometry Part B: Clinical Cytometry. It was also featured as the Journal's cover image.
• "T cell egress via lymphatic vessels limits the intratumoral T cell repertoire in melanoma" in the Nature Immunology.
• "Supervised learning of high confidence phenotypic subpopulations from single cell data" in Nature Machine Intelligence.
• "An open protocol for modeling T cell clonotype repertoires in TCRb CDR3 sequences" in BMC Genomics.
• "Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole slide imaging with accurate single-cell segmentation" in Cell Reports Methods.
• "MYC deregulation and PTEN loss model tumor and stromal heterogeneity of aggressive triple-negative breast cancer" in Nature Communications.

The Wong lab has 2 publications to announce:

1. "Flexible Cyclic Immunoflorescence (cyCIF) Using Oligonucleotide Barcoded Antibodies" in Cancers.
2. “The Hallmarks of Circulating Hybrid Cells” editorial in Springer Nature.

The Brody lab has 2 publications to announce, both in collaboration with Dr. Jordan Winter's lab at Case Western:

1. "Increased glucose availability sensitizes pancreatic cancer to chemotherapy" in Nature Communications.
2. "Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors" in Nature Cancer.

The Pucci lab has recently published, "Sequential chromogenic immunohistochemistry: spatial analysis of lymph nodes identifies contact interactions between plasmacytoid dendritic cells and plasmablasts" in AACR's Cancer Research Communications.

The Brody lab has 2 publications to announce:

1. "Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity" in NAR Cancer.
2. "A Novel 3DNA® Nanocarrier effectively delivers payloads to pancreatic tumors" in Translational Oncology.

The Schedin lab has recently published, "Isogenic Mammary Models of Intraductal Carcinoma Reveal Progression to Invasiveness in the Absence of a Non-Obligatory In Situ Stage" in Cancers. Read the paper here.

The Maxson lab has 4 publications to announce:

1. Carratt SA, Kong GL, Curtiss BM, Schonrock Z, Maloney L, Maniaci BN, Blaylock HZ, Baris A, Druker BJ, Braun TP, Maxson JE. Mutant-SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms. Blood. 2022, 140(6):644-658. DOI: 10.1182/blood.2021014777.
2. Braun TP, Estabrook J, Schonrock Z, Curtiss BM, Darmusey L, Macaraeg J, Enright T, Coblentz C, Callahan R, Yashar W, Taherinasab A, Mohammed H, Coleman DJ, Druker BJ, Demir E, Lusardi T and Maxson JE. ASXL1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors. Leukemia. 2022, 37(2):478-487. DOI: 10.1038/s41375-022-01792-x.
3. Maniaci BN, Chung J, Sanz-Altamira P, DeAngelo DJ, and Maxson JE. A novel Colony Stimulating Factor 3 Receptor activating mutation identified in a patient with Chronic Neutrophilic Leukemia. Haematologica. 2023 (epub ahead of print). DOI: 10.3324/haematol.2022.281828.
4. Carratt SA, Kong GL, Coblentz C, Schonrock Z, Maloney L, Weeder B, Yashar W, Callahan R, Blaylock H, Coleman C, Coleman D, Braun TP, Maxson JE. RUNX1::ETO translocations must precede CSF3R mutations to promote acute myeloid leukemia development. Leukemia. 2023 (epub ahead of print). DOI: 10.1038/s41375-023-01862-8.

Accolades/Funding:

At the Dec. 7 Town Hall meeting, Director Brian Druker, M.D., announced that Lisa Coussens, Ph.D., and Shivaani Kummar, M.D., will serve as OHSU Knight Cancer Institute deputy directors effective immediately. Druker said the two strong leaders – representing the clinic and the lab, respectively – are well-equipped to step into these critical roles. If you missed last week’s Town Hall meeting, you can watch the recording.

Congratulations to Dr. Lisa Coussens, who is one of six scientists at OHSU who are among world's most highly cited per the consulting firm Clarivate. Lisa made the list in the field of molecular biology and genetics. Clarivate compiles an annual list of researchers who’ve shown significant and broad influence reflected in the publication of multiple papers frequently cited by their peers. Read more on OHSU Now.

Congratulations to Dr. Kate Byrne, who has been awarded a grant from the Robert L. Fine Cancer Research Foundation funded for 2 years. The title of the grant is, "Harnessing CD4 T cells in the pancreatic tumor microenvironment."

Congratulations to John McClatchy, graduate student in the Agarwal lab, who is a recent recipient of the F31 Ruth L. Kirschstein Predoctoral Individual National Research Service Award to study role of inflammation in TET2-mediated clonal hematopoiesis.

Congratulations to Michael Parappilly, student in the Wong lab, who was recently selected as one of the OSLER TL1 awardees. 

Congratulations to Victoria Schuster, graduate student in the Ruhland lab, who is a recipient of the 2022-23 N.L. Tartar Trust Fellowship. The Fellowship is intended to be used for supporting research endeavors and research career development in the School of Medicine.

Congratulations to Breanna Maniaci, graduate student in the Maxson lab, who has been awarded an F31, which will support her thesis work on understanding oncogenic CSF3R signaling in patients with Chronic Neutrophilic Leukemia.

Congratulations to Margaret Haerr, graduate student in the Byrne lab, who is a recipient of the 2022-23 N.L. Tartar Trust Fellowship. The Fellowship is intended to be used for supporting research endeavors and research career development in the School of Medicine.

Ashley Anderson, graduate student in the Wong lab, received an NRSA funded by the NCI for her project, ”Mechanisms of Neoplastic Hybrid Cell Dissemination in Colorectal Cancer.”

Ashley Anderson, graduate student in the Wong lab, was interviewed by the ARCS Scholars regarding her experience as a trainee at OHSU. The video will be posted in October.

Dr. Ranish Patel, surgical resident with the Wong lab, abstract accepted for presentation at the American Pancreatic Association annual meeting 2022.

Dr. Adam Tuttle, postdoc in the Nechiporuk lab, has made the cover of the September 2022 issue of the Journal of Neuroscience. See it here.

The Maxson lab made the cover of the August 2022 issue of Blood. See it here.

Congratulations to Michelle Ozaki, graduate student in the Schedin lab, who is the recipient of the 2022 Associate Dean's Award For Exemplary Contributions to the Graduate Program.

The graduate program in Biomedical Sciences (PBMS) held its annual retreat on Friday, April 22. Two of our own graduate students, both in the Integrated Cancer Biology Hub, won awards for their presentations:

• Best poster prize awarded to Jennifer Finan (Jonathan Brody’s Laboratory)

• Best talk prize awarded to Ashley Anderson (Missy Wong’s laboratory)

Congratulations to Mona Mohammadhosseini, graduate student in the Agarwal lab, who is a recipient of the F31 Ruth L. Kirschstein Predoctoral Individual National Research Service Award in April 2022.

Congratulations to Dr. Amy Moran who has recently been awarded funding from the OHSU Technology Transfer Early-stage Technology Fund.

Congratulations to Dr. Pepper Schedin and the Schedin lab whose paper, “Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes” published in Nature Communications, is the School of Medicine’s Paper of the Month. 

Congratulations to Ashley Anderson, graduate student in the Wong lab, who has received a Medical Student Grant from the Melanoma Research Foundation.

Publications:

Dr. Pepper Schedin and colleagues recently published, "Young-Onset Breast Cancer Outcomes by Time Since Recent Childbirth in Utah" in JAMA Network Open. The publication was also featured on OHSU Now.

The Agarwal lab and AML team have recently published, "Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia" in Blood Advances. Read the paper here.

The Wong lab has two publication-related announcements:

• A collaborative study between Wong, Gibbs, Wu and Chang labs, with partnership with Dr. Alison Skalet. In review: "Circulating neoplastic-immune hybrid cells predict metastatic progression in uveal melanoma" in Cancers.
• Review published: "Circulating Cells with Macrophage-like Characteristics in Cancer: The Importance of Circulating Neoplastic-Immune Hybrid Cells in Cancer" in Cancers.

Dr. Adam Tuttle, postdoc in the Nechiporuk lab, has recently published, "c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases" in the Journal of Neuroscience.

The Maxson lab has recently published, "Mutated SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms" in Blood.

Jeff Tyner, Ph.D. and the OHSU AML team have published, "Integrative analysis of drug response and clinical outcome in acute myeloid leukemia" in Cancer Cell.

Sanjay Malhotra, PhD and the Malhotra lab have recently published, "SU086, an inhibitor of HSP90, impairs glycolysis and represents a treatment strategy for advanced prostate cancer" in Cell Reports Medicine.

Amy Moran, PhD, in conjunction with Dr. Jen Wargo's group, has recently published "Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy" in Nature.

Jonathan Brody, PhD has recently published two papers:

• "Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors" in Nature Cancer.
• "HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms" in Cancers.

Amy Moran, PhD and the Moran lab has recently published, "Androgen receptor activity in T cells limits checkpoint blockade efficacy" in Nature.

Katie Blise, graduate student in the Goecks lab and predoctoral trainee in the ICSB T32 training program (mentors: Drs. Lisa Coussens and Jeremy Goecks), has a recent 1st author publication titled, "Single-cell spatial architectures associated with clinical outcome in head and neck squamous cell carcinoma" in Nature-Precision Oncology.

Accolades/Funding:

Congratulations to Sarah Bernhardt, Ph.D., who is a postdoctoral scholar in the Schedin lab, who has been awarded a Prevent Cancer Foundation Fellowship.

Congratulations to Amy Moran, Ph.D. and the Moran lab which has won the Prostate Cancer Foundation's 2021 Young Investigator Award.

Congratulations to Karin Rodland, Ph.D. who has recently received the PNNL Lab Director’s Award for Lifetime Achievement in Science or Technology.

Congratulations to Missy Wong, Ph.D. and the Wong lab whose paper, "Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors," published in Scientific Reports is the School of Medicine's Paper of the Month. Read the story on OHSU Now.

Congratulations to the following postdoctoral and predoctoral trainees who have been awarded the T32 training grant from CDCB: Tahereh Ziglari, PhD, postdoctoral scholar in the Pucci lab, Benjamin Sarno, PhD, postdoctoral scholar in the Mills lab, Katie Blise, graduate student in the Goecks lab, and Mona Mohammadhosseini, graduate student in the Agarwal lab. Learn more about the T32 training program and trainee projects here.

Congratulation to Philip Copenhaver, Ph.D. who has been awarded the Allan J. Hill, Jr. Award for Basic Science. The award recognizes excellence in teaching by honoring a full-time faculty member in basic science.

Congratulations to Hsin-Yun Lin, M.S., graduate student in the Agarwal lab, who has been selected to receive the AACR-Doreen J. Putrah Cancer Research Foundation Scholar-in-Training Award. Read more here.

Congratulations to the Megan Ruhland, Ph.D. and her lab who have been awarded a grant from the Harry J. Lloyd Charitable Trust. 

Congratulations to Breanna Maniaci, graduate student in the Maxson lab, who has been awarded the ASH Minority Hematology Graduate Award.

Congratulations to Lisa Coussens, Ph.D. who has been elected as American Association for Cancer Research President-Elect for 2021-2022. Learn more here.

Congratulations to Gordon Mills, MD, Ph.D. who has been awarded the 2021 Career Innovator Award from the Society of Gynecological Oncologists for his lifetime contributions to research and training in Gynecological Oncology.

Congratulations to Breanna Caruso, PhD Candidate in the Moran lab, who was awarded an F31 Ruth L. Kirschstein Predoctoral Individual National Research Service Award in February 2021.

Congratulations to Robert Eil, M.D., Ph.D. who is a 2021 AACR-MPM Oncology Charitable Foundation Transformative Cancer Research grantee for his project, "Targeting the ionic immune checkpoint on T cell antitumor function."

Congratulations to Naoki Oshimori, Ph.D. who has recently received R01 funding for the project, "“Mechanisms of cellular crosstalk in tumor-promoting niche formation.”

Congratulations to Julia Maxson, Ph.D. who is a 2021 Women in Academic Health and Medicine (WAHM) Awardee. Dr. Maxson received the Mentorship award which is given to a faculty member who goes above and beyond their duties, and exemplifies a deep commitment to fostering the professional and personal development of women and non-binary students, residents, fellows, post-docs, and faculty.

Congratulations to Benjamin Sarno, Ph.D. (Post-Doctoral Scholar, Mills lab) who has been awarded the 2020/21 Oregon Health & Science Fellowship for Diversity in Research for his project titled, "Monitoring Therapeutic Response of Triple Negative Breast Cancer Patients by Liquid Biopsy."

Publications:

The Malhotra lab has recently published two articles:

• "Harnessing the predictive power of preclinical models for oncology drug development" in Nature Reviews Drug Discovery.
• "New Selective Inhibitors of ERG Positive Prostate Cancer: ERGi-USU‑6 Salt Derivatives" in ACS Medicine Chemistry Letters.

The Schedin lab has three publications to announce:

• "Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis" in MDPI Cancers.
• "The definition of pregnancy-associated breast cancer is outdated and should no longer be used," in The lancet Oncology journal.
• "Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer" in Cancer Prevention Research.

The Oshimori lab has published, "A mechanistic basis for the malignant progression of salivary gland tumors" in iScience. Read the paper here.

The Schedin lab has published, "Postpartum breast cancer has a distinct molecular," in Nature Communications. Read the paper here.

The Brody lab has published, "The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria," in the Molecular Cancer Therapeutics journal. The publication coincides with the start of a clinical trial, "A Study to Determine if the Drug, Pyrvinium Pamoate, is Safe and Tolerable in Patients With Pancreatic Cancer."

The Sherman lab has published, "Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts," in Cancer Discovery. Read the paper here.

The Pucci lab has published, "Characterization of the tumor immune microenvironment of sinonasal squamous-cell carcinoma," in the International Forum of Allergy & Rhinology. Read the paper here.

Adrian Baris, graduate student in the Anand lab, has published, "Nucleic Acid Sensing in the Tumor Vasculature," in Cancers. Read the paper here.

Amy Moran, Ph.D. and Megan Ruhland, Ph.D. are contributors on a recently published symposium commentary, "Arthur L. Irving Family Foundation Cancer Immunology Symposium: Supporting the next generation of scientists to lead cancer immunology research," in Cancer Immunology Research. Please come back later for a link to the paper.

Amy Moran, Ph.D. is a contributor on a recently published paper, "Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data," in Nature Biotech. Please come back later for a link to the paper.

The Coussens lab published two papers:

• "Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome," in Cancer Discover. Read the paper here.

• "Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer," in Clinical Cancer Research. Read the paper here.

The Enns lab published, "Hepatocyte Neogenin Is Required for Hemojuvelin-Mediated Hepcidin Expression and Iron Homeostasis in Mice," in Blood. Read the paper here.

Pepper Schedin, Ph.D. and colleagues published, "The definition of pregnancy-associated breast cancer is outdated and should no longer be used," in The Lancet Oncology journal. Read the commentary here.

Karin Rodland, Ph.D. and colleagues published, "Proteogenomic and metabolomic characterization of human glioblastoma," in Cancer Cell. Read the article here.

The Pucci lab published, "Gene Expression Profiling of Lymph Node Sub-Capsular Sinus Macrophages in Cancer," in the journal of Frontiers in Immunology. Read the paper here.

Alex Quackenbush Bartlett and the Schedin lab published, "Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis" in Cancers. Read the paper here.

The Moran lab, in collaboration with Mike Munks and the Ann Hill lab at OHSU, published, "PD‐1‐specific “Blocking” antibodies that deplete PD‐1⁺ T cells present an inconvenient variable in preclinical immunotherapy experiments" in the European Journal of Immunology. Read the paper here.

The Malhotra Lab published, "Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides," in the ACS Medicinal Chemistry Letters journal. Read the paper here.

Karin Rodland, Ph.D. published, "Proteogenomic and metabolomic characterization of human glioblastoma," in Cancer Cell. Read the paper here.

The Pucci Lab has a paper in preprint, "Gene expression profiling of lymph node sub-capsular sinus macrophages in cancer." Read the paper on bioRxiv.

Publications:

The Malhotra Lab published, "Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer" in the British Journal of Cancer. Read the paper here.

The Mills Lab published has two recent publications: 

• "Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines" in Cancer Cell. Read the paper here.

• "Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression" in Elife. Read the paper here.

The Schedin Lab published, "Characterization of weaning-induced breast involution in women: implications for young women’s breast cancer," in NPJ Breast Cancer. Read the paper here.

The Oshimori Lab published, Cancer stem cells and their niche in the progression of squamous cell carcinoma, in Cancer Science. Read the paper here.

CDCB's Dr. Evan Lind and members of the Lind lab recently published, "Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia," in the Proceedings of the National Academy of Sciences of the United States of America. The paper has also been named the "Paper of the Month" by the OHSU School of Medicine. Read the paper here.

A group of OHSU researchers, including CDCB's Dr. Amy Moran, recently published, "A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone," in the Journal of ImmunoTherapy of Cancer. Read the paper here.

The Sherman lab published, Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer, in the Journal of Experimental Medicine. Read the paper here.

The Pucci lab published, Cell Surface Labeling by Engineered Extracellular Vesicles, in Advanced Biosystems. Read the paper here.

The Oshimori lab published, Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression, in Science magazine. Read the paper here.

The Schedin lab's Sonali Jindal published, Comparison of Mortality Among Participants ofWomen’s Health Initiative Trials With Screening-Detected Breast Cancers vs Interval Breast Cancers, in JAMA Network Open. Read the paper here. 

The Schedin lab's Elizabeth Mitchell published, Loss of myoepithelial calponin‐1 characterizes high‐risk ductal carcinoma in situ cases, which are further stratified by T cell composition, in Molecular Carcinogenesis. Read the paper here.

The Walker lab published, NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer, in the Journal for ImmunoTherapy of Cancer which was featured in the spotlight of ACIR's June 11 2020 Weekly Digest.

The Enns lab has three recent publications: 

• "The Ectodomain of Matriptase-2 Plays an Important Non-Proteolytic Role in Suppressing Hepcidin Expression in Mice" in Blood. Read the paper here. 

• "Insights into basic science: what basic science can teach us about iron homeostasis in trauma patients" in Current Opinion in Anesthesiology. Read the review here.

• "Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload" in the Journal of Biological Chemistry. Read the paper here.

Accolades/Funding:

Congratulations to Karin Rodland, Ph.D. who is is a recipient of the Human Proteome Organization’s 2020 Distinguished Achievement in Proteomic Sciences Award.

Congratulations to Samuel Tsang, Ph.D. (Research Assistant Professor, Mills lab) and Aurora Blucher, Ph.D. (Postdoctoral Scholar, Mills lab) who are both OHSU Center for Women’s Health Circle of Giving 2020 awardees.

Congratulations to Amy Moran, Ph.D. whose invited presentation at the Immuno-Oncology Young Investigator's Forum won first place in the research scientist category. Her talk focused on work revealing how androgen receptor activity is a critical determinant of checkpoint blockade efficacy.

Congratulations to the OHSU Knight Cancer Institute's Center for Experimental Therapeutics, directed by Sanjay Malhtora, Ph.D., which has been awarded one of eleven grants from the Indo-U.S. Science and Technology Forum (IUSSTF) to form a virtual network for COVID-19 research. 

Congratulations to Michelle Ozaki, graduate student in the Schedin Lab, who recently received the ACRS Scholar Award and was one of three OHSU students to receive a 2020 National Science Foundation Graduate Research Fellowship.

Congratulations to Philip Copenhaver, Ph.D. who was recently awarded a five-year RF1 grant to investigate how signaling by the Amyloid Precursor Protein (APP) controls neuronal guidance within the developing nervous system.

Congratulations to Mara Sherman, Ph.D. who is the recipient of a Pew Scholar award. As part of the 2020 class of the Pew-Stewart Scholars Program for Cancer Research, Dr. Sherman will receive a four-year grant to advance innovative research into the development, diagnosis, and treatment of cancer. Learn more here.

Congratulations to Adrian Baris (Anand lab) and Reed Hawkins (Moran lab), two CDCB students who have each received a training grant from the NIH Ruth L Kirschstein T32 Program in Enhanced Research Training (PERT), and will spend one year in intensive training that emphasizes the competencies they will need to develop a successful career in biomedical research.

The OHSU School of Medicine's Office of Graduate Studies has released the 2020 report of career outcomes for its 518 PhD recipients, including Cancer Biology and Cell & Developmental Biology program graduates. Read the report here.

CDCB's Philip Copenhaver, Ph.D. and his fourth-year M.D. mentee, Eric Nomura, were featured in OHSU News article "Scholarly projects showcase student creativity from the heart", which explores how the pair developed Eric's capstone project.

Publications:
Lind Lab published, Acute myeloid leukemia-induced T-cell suppression can be reversed by inhibition of the MAPK pathway, in ASH's Blood Advances.

Moran Lab published, OX40 Agonist Tumor Immunotherapy Does Not Impact Regulatory T Cell Suppressive Function, in the Journal of Immunology.

Sherman Lab published, A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression, in AACR's Cancer Discovery.

Accolades/Funding:
Congratulations to Sara Courtneidge, Ph.D., who has been elected Fellow of the American Association for the Advancement of Science. Read more on OHSU Now.

Congratulations to Ferdinando Pucci, Ph.D., who has received over $600,000 in grants from the Collins Medical Trust, Medical Research Foundation, V Foundation, and Cancer Research UK in his first year at OHSU.

Congratulations to Sara Courtneidge, Ph.D., awarded the 18th Rosalind E. Franklin Award for Women in Science by the National Cancer Institute. Learn more about the award.

Congratulations to Nechiporuk Lab for publishing Retrograde Ret signaling controls sensory pioneer exon growth in eLife.

Congratulations to Moran Lab for publishing OX40 Agonist Tumor Immunotherapy Does Not Impact Regulatory T Cell Suppressive Function in The Journal of Immunology. 

See profiles of CDCB faculty Melissa Wong, Ph.D., Amanda Lund, Ph.D., and Anupriya Agarwal, Ph.D., among others featured in Onward's Forces of Change.

Congratulations to Amanda Poissonnier, Ph.D., awarded a CRI/Irvington Postdoc Fellowship, a training fellowship from the Cancer Research Institute, for her project, Relieving immune suppressive pathways in breast cancer to improve outcomes.

Congratulations to Amanda Lund, Ph.D., chosen for the Cancer Research Institute's Lloyd J. Old STAR Program. Each STAR will receive $1.25 million over five years for research contributing to cancer immunotherapy.

Congratulations to Takahiro Tsujikawa, M.D., Ph.D., awarded as a best young physician scientist in Japan, by the Otorhinolaryngological Society of Japan. See photo

Congratulations to Ryan Lane, recipient of the 2019 Outstanding Journal Article: Basic Science award, for his research article, IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin.

Congratulations to Lisa Coussens, Ph.D., who has recently been honored as a fellow of the American Association for Cancer Research Academy. Read more on the Knight News blog, and on AACR.

CDCB's Pepper Schedin, Ph.D., will be giving  the talk, Young Women's Breast Cancer - What is the Role of Pregnancy? at the Susan G. Komen event, the 2019 Regional Breast Cancer Issues Conference.

Congratulations to Amanda Lund, Ph.D., and Sudarshan Anand, Ph.D., the first to receive KCI's new leadership awards funded by the Betty Hise Foundation. 

Congratulations to Caroline Enns, Ph.D., an author on SOM's January, 2019 Paper of the Month, VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy.